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Ctgf , Connective tissue growth factor

Guidelines and Protocols Advisory Committee: Cobalamin (vitamin B12) Deficiency - Investigation & Management [Internet]

Some individuals may start with weekly injections for a period and then transition to monthly injections for maintenance

Pemetrexed is in a subcategory of antimetabolite drugs called folic acid analogs

When B12 is deficient, demyelination occurs, particularly affecting the spinal cord's posterior columns (responsible for proprioception and vibration sense) and lateral corticospinal tracts (controlling motor function)

Most patients notice increased energy and mental clarity within hours to a few days, while weight loss effects accumulate over weeks of consistent use