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For gene ontology (GO) analysis, the Seurats FindMarkers output for the specified groups was used to plot gene ontology terms with the barcodeplot functions from limma 131

In this demographic, cardiovascular medications and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently employed to manage related conditions, yet they can potentially compromise renal function through mechanisms such as fluid depletion or drug interactions (Ribeiro et al., 2022)

Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study

Bone histomorphometric analysis Dynamic histomorphometry was performed to assess mineralizing surface to bone surface (MS/BS), mineral apposition rate (MAR), and bone formation rate normalized to bone surface (BFR/BS) [61]

doi:10.1007/s12035-023-03626-y 7