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In early clinical trials of GDNF/NRTN, some patients developed antibodies against the delivered factor, potentially contributing to the loss of therapeutic effect over time [130, 131]

Walter F, OBrien A, Concannon CG et al (2018) ER stress signaling has an activating transcription factor 6 (ATF6)-dependent off-switch

W.WangS.WangJ

De novo transcriptome assembly and comparative analysis elucidate complicated mechanism regulating Astragalus chrysochlorus response to selenium stimuli

In some mild cases, it is enough, but for more complicated metabolic disorders like tetanus and paresis, treatment with calcium and magnesium are also recommended