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However, the gradual development of resistance by tumor cells to these treatments poses a significant challenge in the management of gliomas [44, 45]

Originally identified in intestinal stem cells, LGR5 is now recognized as a marker of CSCs in GBM, colorectal, gastric, and hepatocellular cancers, where its expression is correlated with increased tumor initiation, metastatic potential, and poor prognosis

No significant difference was observed among the other carbon sources, although sucrose and maltose yielded lower EGT levels compared to glucose, likely due to incomplete disaccharide utilization