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Failure of MK-801, to attenuate kainate-induced cell damage under excitotoxic conditions has led to the conclusion that OLCs do not express NMDARs (Yoshioka et al., 1995) and that excitotoxicity in oligodendrocytes is mediated through non-NMDA glutamatergic receptors (Yoshioka et al., 1995, 2000

The plasma concentrations of ferulic acid were also almost constant between 2 and 14 h after intake of Pycnogenol and the steady state concentrations after multiple doses appeared high compared to the single dose (32)

[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Mandal P., Lanaridi O., Warth B., Ansari K.M

(36) Resveratrol attenuates hypoxia-induced neuron death and brain inflammation, while apigenin promotes the growth of new, healthy neurons (a process known as neurogenesis) in animal models

Combining them with a peptide that also increases nitric oxide production could theoretically produce excessive vasodilation, leading to dangerous blood pressure drops

Thats when supplementation becomes essential