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J Biol Chem 290(23):1466814678

The inhibition of the IRE-1/XBP-1 signaling pathway suppresses M1 polarization and alleviates LPS-induced lung injury (173)

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This approach has been successfully established after intake of Pycnogenol ( The gold standard for pharmacodynamic evaluations are randomized, placebo-controlled double-blinded clinical trials with healthy volunteers or patients