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Details can be found in Supplemental Methods

doi: 10.3390/ijms21228551 79 PhadnisVVSniderJVaradharajanVRamachandiranIDeikAALaiZWet al

Morphologically, no significant abnormalities were seen in the testes and spermatozoa of mice after SNGPX4 KO ( 2.5 GPX5 Glutathione peroxidase 5 (GPX5), an epididymis-specifically expressed selenium-free antioxidant enzyme, was first isolated and identified in the epididymal tissues of mice (Taylor et al., 2013)

7A, B), without an effect on 5hmC association (Fig

Liver function biomarkers (ALT, AST), oxidative stress indicators (GPx), and inflammatory cytokines (IL-1b) were assessed alongside histopathological analysis

Unlike conventional cell death pathways such as necrosis and apoptosis, ferroptosis has distinctive features