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10.1016/j.bbrc.2018.11.124 Biochem Biophys Res Commun

534,535 Resting membrane of aged astrocytes remains highly hyperpolarised (~80 mV), the input resistance increases somewhat with age, thus reflecting morphological shrinkage

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On the other hand, when severe intestinal inflammation is present, the vagus nerve can also transmit these harmful inflammatory signals (such as gut-released IL-1) to the CNS, inducing microglial activation (Rosas-Ballina et al., 2011)