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In the early 1960s, researchers found that workers with chronic exposure to organophosphates, mainly in insecticides and after sheep dipping, experienced persistent central nervous system (CNS) changes (153)

Those meeting the criteria were manually validated to ensure accurate y- and b-ion detection with overlapping sequence coverage

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This was the upper limit of quantitation of assays performed in the early days of research regarding paracetamol poisoning and has empirically been maintained as the definition for liver injury since then *

doi: 10.1016/j.biopsych.2009.04.033 140 ShadfarS.ParakhS.JamaliM

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