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IAC, the reaction product of TEMPO and presumably also TEMPOL, showed protective effects in animal models of various diseases, including colitis, Alzheimers disease, and diabetes (Novelli et al., 2007

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In human cells, knockdown of Grx3 was associated with loss of FeS cluster-dependent, cytosolic aconitase activity (60% decrease) and concomitant disruption of cellular iron homeostasis

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[DOI] [PubMed] [Google Scholar] 9.Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM