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The discovery was then followed up by Chen et al., where the group identified an increase of anti-SR-A and anti-MARCO IgG in SLE patients when compared to controls (327, 374)

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Beyond this mechanism, activation of the TST pathway by, for instance, thiosulfate leads to activation of the NRF2 signaling pathway, demonstrating the potential of small molecule interactions to therapeutically target this pathway [42,114] (see Fig