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Animal models for autoimmune demyelinating disorders of the nervous system

Additionally, it is known that markers of OS in the brain, such as lipoperoxidation, are higher in male brains than female brains 21,22

For instance, amifostine exhibits remarkable individual differences in efficacy and toxicity: it requires alkaline phosphatase (ALP) for conversion in vivo to exert its effects, and varying ALP levels among tumor patients affect the production of its active metabolites, thereby influencing therapeutic efficacy (192)

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