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Preclinical evidence shows the significance of microbial metabolites and immune signaling in driving these effects, and recent clinical studies further supports these findings (Touchefeu et al., 2014

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J Neuroinfect Dis 5:110 Li J-M, Zhao Y, Sun Y, Kong L-D (2020) Potential effect of herbal antidepressants on cognitive deficit: pharmacological activity and possible molecular mechanism

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Lastly, although the hangover symptom surveys (AHS and AHSS) showed no significant differences between the GSH and placebo groups overall, the subjective nature of these surveys may have influenced the results