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found that uridine significantly alleviated lung injury, inflammation, tissue iron levels, and lipid peroxidation in sepsis-induced ALI mice, partially through ACSL4 downregulation and SLC7A11, GPX4, and heme oxygenase 1 (HO-1) upregulation

The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence