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SIRT2 has been reported to induce Nrf2 activation and GSH production 140 , and pharmacological activation of SIRT2 has been shown to inhibit IAV replication 70

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Without sufficient cysteine from sources like NAC, the body's antioxidant defenses quickly become depleted, leaving cells vulnerable to premature death and structural degradation

This ultimately initiates the final stage of apoptosis through the activation of caspases 8

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