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Rat Two- and eighteen-month-old adult lean SpragueDawley rats ( n = 12

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Pro-inflammatory cytokines induce signaling cascades that can lead to downregulation of stabilizing factors such as sonic hedgehog [3, 58], to activation of effector proteins such as matrix metalloproteinases [33], and to the formation of reactive oxygen species [47]

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

To elucidate the involvement of RGMa in the neural differentiation of NSCs, we cultured neurospheres, which are clusters composed of NSCs from neurogenic niches, as described previously 35,36 (Fig