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Gecele M, Francesetti G, and Meluzzi A

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Conversely, loss of HDAC3 increased ARE activation activity from these sites and diminished cell cycle activity, suggesting that HDAC3 inhibitors may hold promise as a CaP treatment to restore an AR cistrome with more benign features [66]

By integrating shared molecular signatures from plasma EV proteomic and single-cell transcriptomic analyses, we aimed to cross-validate our findings and ensure robust interpretation despite the limitations of the sample size for the sequencing

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This viral interference forces the cell to shift away from efficient aerobic respiration (oxidative phosphorylation) and toward less efficient anaerobic glycolysis, a phenomenon known as the Warburg effect