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Recently, several new cachexia-related factors, such as the growth factor GDF15 and the chemokine LCN2, which participate in cachexia through mechanisms that amplify inflammatory signals beyond traditional pathways, have been reported (Table 2)

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Overall, our results propose a novel therapeutic strategy for APAP-induced liver injury, involving hepsin administration alongside a low dose of NAC to improve treatment effectiveness and address current limitations

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Subsequent protein expression and purification procedures were maintained under identical conditions to monovalent nanobody production

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