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However, muscle uptake of carnitine from the blood is a long process and is not highly sensitive to additional carnitine uptake [271], indicating that muscle cells have a certain degree of saturation of carnitine uptake and that additional intake has a limited effect on muscle carnitine levels when the energy demand is low or when the metabolic status is stable

Grundy, S

Nonetheless, further in-depth research is needed to understand the molecular mechanisms of lactylation for developing therapies targeting lactate-lactylation pathways

Dose translation from animal to human studies revisited

Acknowledgements We thank the radiology department in the National Hospital for free access to the CMR equipment

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