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[17] (UK sample) reporting an effect size d = 2.6 for ACC glutamate difference between 1-month remitters and nonremitters, we required a sample of at least 22 patients to demonstrate 50% of the reported effect ( d = 1.3), with 5% type 1 and 20% type 2 error rates

The 1990 method used a shorter pre-incubation time and a higher concentration of FAD than either of the other two methods

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