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Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

The mice were monitored daily for health, and survival was recorded on days when the mice met the NIH Animal Care and Use Committee-approved humane criteria for euthanasia

All datasets generated and/or analyzed during this study are provided in Supplementary Data 1

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Phospholipase A 2 (PLA 2 ) is the key initiating enzyme of the arachidonic acid cascade, responsible for catalyzing the hydrolysis of membrane phospholipids to release arachidonic acid