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Although HO-1 is commonly associated with cytoprotection and inhibition of cell death processes, excessive activation of HO-1 releases large amounts of Fe 2+ , leading to the accumulation of unstable iron pools and corresponding deleterious cyclic effects that exacerbate oxidative stress, presenting a dual effect that characterizes HO-1 as a double-edged sword

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These proteins play an important role in DNA damage repair, autophagy, apoptosis, energy metabolism, inflammatory response and mitochondrial health

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Neuropsychobiology, 1983