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Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states

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Munoz-Rojas, A

425 Age has traditionally served as a distinguishing factor between primary and secondary HLH

The adverse effects of diabetes extend beyond the endothelium, as hyperglycemic conditions impact microglia activation, leading to increased proinflammatory cytokine production and ROS formation in both the endothelium and parenchymal microglia