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Low levels of B12 can lead to nerve damage, as the vitamin is essential to producing myelin, which protects nerve cells from damage

doi: 10.1161/CIRCULATIONAHA.109.848911

Common triggers of skeletal muscle cramps: Include muscle overuse, prolonged exercise (especially in heat), prolonged sitting or standing, and idiopathic nocturnal cramps

It's a common fit for anyone feeling run down or following a plant-based diet where B12 can run low

The Drug Affinity Complex (DAC) is a maleimidopropionic acid group attached to Lys8 of the peptide

Second, nighttime application means no interference from sweat, hats, or UV exposure