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Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment

Discussion Preclinical studies have proved the anti-leukemic effects of targeting glutamine metabolism

Sousa-Junior A, Yang C-T, Korangath P et al (2022) A predictive pharmacokinetic model for immune cell-mediated uptake and retention of nanoparticles in tumors

90 LupoliF.VannocciT.LongoG.NiccolaiN.PastoreA

Nox is activated in response to physical stimuli (shear stress, pressure), growth factors (platelet-derived growth factor, nerve growth factor, fibroblast growth factor, transforming growth factor ), cytokines (tumor necrosis factor, interleukin 1), metabolic factors (hyperglycemia, hyperinsulinemia, glycation end products, free fatty acids), G protein-coupled receptor agonists (serotonin, thrombin, endothelin, angiotensin II, bradykinin)

Front Oncol (2020) 10