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doi: 10.1038/s41467-020-17881-3 16 YanJHorngT

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Inhibition of the EMT by sulforaphane in thyroid cancer cells has been associated with upregulation of an epithelial marker, E-cadherin, and downregulation of a transcription factor (SNAI2), a filament protein (vimentin), and various enzymes (matrix metalloprotein [MMP]-2 and MMP-9) known to contribute to EMT and promote migration (32)

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Details of the CpG island size, location, and CpG content are described in the supplementary methods (Supplementary Table S3)

Due to various limitations, such as the stability of models, properties of chemicals, and differences between experimental animal species and humans, models currently in use can only represent one or several views of the pathophysiological progress of PD (Miller, 2007