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Hemin enhances radiosensitivity of lung cancer cells through ferroptosis

This can be observed in the modulation of BCL2 family protein levels by ROS, as heightened pro-apoptotic BAX and BAK1 levels accompanied by a decrease in anti-apoptotic BCL2 and BCL2-like 1 (BCL2L1/BCL-XL) expression are observed in squamous cell carcinoma cells [114]

Cancer 8 , (2020)

323 CaSR promotes cell proliferation and anti-apoptosis to contribute to vascular remodeling These variants contribute to the upregulation of CaSR expression and activity, which in turn enhances Ca influx and Ca-induced cytosolic Ca release into PASMCs, promoting cell proliferation and contributing to vascular remodeling

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