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The discrepancies in the biotoxicity of ferroptosis-inducers in animal models and humans contribute to erroneous assessments of the safety and efficacy of therapies

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On the one hand, ERS serves as an inducer of autophagy

Li Y, He X, Sun B, Hu N, Li J, You R et al (2024) Combined exposure of beta-cypermethrin and emamectin benzoate interferes with the HPO axis through oxidative stress, causing an imbalance of hormone homeostasis in female rats

PMID: 41843713 Folia Histochem Cytobiol Ginsenoside Rg3 inhibits Ang II-induced cardiac fibrosis via the GLP-1 receptor signaling pathway

Several compounds, including vorinostat and romidepsin, which inhibit multiple HDACs, have been approved by the FDA due to their excellent performance in treating cutaneous (157) and peripheral (158) T-cell lymphoma