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et al., 2021

It affects every cell in the body, but the most visible effect is on the skin

We then performed untargeted metabolomics and found 1154 nonredundant metabolites in the BM microenvironment (Fig

10.1126/science.1091230 Science 113 MaillouxR

To identify glutathione-overproducing mutants, acrolein was used as a selective agent, given glutathiones key role in protecting cells from acrolein-induced toxicity (Mano et al., 2009

However, due to the extensive cross-talk of KRAS-mediated signalling pathways, it is difficult to achieve effective inhibition of signalling pathways only by inhibiting a single key molecule, and joint inhibition of multiple key molecules is often required