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16 weeks 5 vials Lower vial count but larger draw volumes per dose 26 weeks 7 vials Standard Phase 2 duration 32 weeks 8 vials Phase 2 T2D study duration 68 weeks 17 vials Long-cycle planning matches REDEFINE 1 and 2 Insulin Syringes (U-100, 1 mL) One syringe per weekly injection

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10.1098/rstb.2011.0394 21 FarrellC.DoolinK.O LearyN.JairajC.RoddyD.TozziL.et al (2018)

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Patients on lower doses (200 to 300 mcg) may tolerate longer continuous periods before receptor sensitivity concerns arise, while patients on higher doses (400 to 500 mcg) may benefit from more frequent cycling