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Description

Pract Diab Int

First, direct pharmacological interactions where one compound changes how another works in the body

Most discussion about combined use is based on: extrapolations from independent studies theoretical complementarity of mechanisms observations in research-community settings Because controlled combination studies are rare, proposed interactions remain speculative

(MMP)

Three non-selective serotonin-receptor agonists were approved by FDA: fenfluramine (1973-1997), the combination phentermine-fenfluramine (1992-1997), and dexfenfluramine (1996-1997)