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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

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Through September 30, publishing division highlights were Partworks (up 9.3%) and Hachette Book Group (up 2.2%), which offset the anticipated decline at Hachette UK due to unfavorable comparison with the hugely successful Q3 2016 publication of Harry Potter and the Cursed Child