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These changes inhibit -ketoglutarate-dependent dioxygenases and activate the NRF2 stress pathway, promoting tumorigenesis [211]

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In some people, coffee can cause looser stools or even diarrhoea, but it rarely causes constipation, and may even help prevent it

This will not only improve our understanding of ferroptosis and GIME but also provide a new solution for glioma immunotherapy resistance, a new breakthrough point for glioma treatment