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Ultrapure water (18.2 M cm resistivity, Arium Comfort H2O-I-1-UV-T from Sartorius, Goettingen, Germany) or LC-MS grade water (LiChrosolv, Merck KGaA) was used throughout

Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

AOD 9604 went down this path for a specific indicationobesitybut did not complete it successfully to gain approval

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It has been shown to stimulate the production of type II collagen, which is a key component of cartilage tissue, and to inhibit the production of enzymes that can break down cartilage.Furthermore, AOD-9604 has been shown to be safe and well-tolerated in clinical trials

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