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Heme arginate can stabilize these variants and restore heme-binding activity in cell models (78)

Direk N, et al

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The Journal of Nutrition, 134(3), 489492

Body weights were recorded daily throughout the treatment period

This interaction suggests that disruption of the SKI complex, due to factors such as FOCAD (9p21.3) deletion or microsatellite instability-high (MSI-H) status, creates a dependency on PELO and HBS1L for tumor cell Survival