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Long-standing baseline cognitive deficits reduced cognitive reserve, cumulative antipsychotic exposure, and histories of institutionalization may lower the threshold for meeting clinical dementia criteria during normative aging, even in the absence of primary neurodegenerative pathology (2, 23, 24)

Raines T, Jones P, Moe N, Duncan R, McCall S, Ceremuga TE

In contrast, decreasing trends were observed in high-density lipoprotein (HDL)-related variables, the ratio of polyunsaturated fatty acids to total fatty acids, the ratio of polyunsaturated fatty acids to monounsaturated fatty acids, the ratio of omega-6 fatty acids to total fatty acids, and the ratio of linoleic acid to total fatty acids (Figures S2 and S3)

In a phase I clinical trial, DNX-2401 exhibited promising results, as favorable clinical responses were observed in 20% of patients with recurrent glioblastoma who were treated via intratumoral injection

The probiotic Lactobacillus plantarum induces Nrf2-mediated antioxidant signaling and eNOS expression, thereby improving myocardial diastolic function 163