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Therefore, the interplay between autophagy and inflammatory cytokines may be a key factor in both the progression of disc degeneration and the postoperative recovery process

Similarly, in oncology, zinc-based nanomaterials have been used to induce ER stress and the UPR, culminating in immunogenic cell death and enhancing the efficacy of immune checkpoint blockade therapies 181,182

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These situations include allergy to sclerosing agents, fear of needles, and blood vessels too small for a fine needle (Wittens 2015