Pahwa, Rajesh|Lyons, Kelly E|Hauser, Robert A Ropinirole therapy for Parkinsons disease Expert Review of Neurotherapeutics
because the ratio of the four peptides is fixed by the manufacturer, the researcher cannot adjust one component independently of the others
Therefore, the changes observed in the pain threshold test, OFT, and their reflection on brain electrical activity (EEG) are suggested to be a direct consequence of monoamine depletion and oxidative stress induced by reserpine 52

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doi: 10.1038/tp.2016.61 303 ZarateCASinghJBCarlsonPJBrutscheNEAmeliRLuckenbaughDAet al
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