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Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP CTF

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Therefore, pharmacological doses of coenzyme Q 10 as high as 1,200 to 3,000 mg/day for adults and 30 mg/kg/day for children are usually needed to relieve symptoms in patients with coenzyme Q 10 deficiency (26)

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Epley also explains how to reduce social anxiety using simple and easily accessible science-supported tools