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Nordihydroguaiaretic acid: from herbal medicine to clinical development for cancer and chronic diseases

Y.JeeH.JunH.ChoH.ParkD.et al (2023)

Additionally, Dihexas small molecular weight of 750 Da allows blood-brain barrier penetration approximately 1000-fold more efficient than BDNF, which is too large to cross the BBB effectively when administered peripherally

This compound serves as a frontline defense against free radicalsunstable molecules that can damage cells if left unchecked

Clarifying the core mechanisms and key influencing factors of the contradictory conclusions on the regulatory effects of mitophagy is not only of great significance for in-depth understanding of the role of mitophagy in the occurrence and development of related diseases, but also provides important theoretical support for subsequent disease prevention and treatment strategies targeting mitophagy