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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

Early studies with the T-cell binding OKT3 anti-CD3 antibody have, however, reported overzealous immune stimulation such as non-specific systemic cytokine release through binding of the Fc region to immune cell expressing Fc gamma receptors (FcR) 5,6

This variability makes precise dose-response optimization harder than with injection, where absorption is highly predictable

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