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In some embodiments, a pharmaceutical composition contains about 0.1 pg to 1000 pg, at least about 0.5 pg, at least about 0.8 pg, at least about 1 pg, at least about 5 pg, at least about 8 pg, at least about 10 pg, at least about 50 pg, at least about 100 pg, at least about 500 pg, or at least about 1000 pg of encapsulated mRNA

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These include phosphoproteins that regulate transcriptional control: STAT3 [S727] and CREB [S133]

In some embodiments, the otic formulation or composition comprises about 40% by weight of the carbomer

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