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Regional Serotonin Synthesis Pattern In a 2004 Life Sciences study by Tohyama et al

Mice treated with 7.5 or 15 mg of colistin/kg of body weight/day for 7 days showed signs of apoptosis involving mitochondrial Bcl-2 and Bax, death receptor (upregulation of Fas, FasL, and Fas-associated death domain), and endoplasmic reticulum (ER) pathways (upregulation of Grp78/Bip, ATF6, GADD153/CHOP and caspase-12), suggesting that mitochondrial and ER stress upon colistin exposure [58]

Global, regional, and national burden of osteoarthritis, 19902020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021