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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors

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Figure 2 While depletion of B cells and loss of antibodies is a reported side-effect of Daratumumab treatment, we also observed strong depletion of CD38+ CD8+ T cell subsets that was previously unreported ( Figure 2B ) ( Figure 2B )