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Briefly, CT and MSS fibroblast were lysed in MES buffer provided by the kit (1.5 10 7 cells/mL), and centrifuged at 10,000 g for 15 min, at 4 C

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For passaging of organoids, the collagen domes were incubated with 1 mg ml 1 collagenase from Clostridium histolyticum (Sigma-Aldrich) for 30 min at 37 C, and digestion monitored using bright-field microscopy (small clumps of cells)

11a, b and Supplementary Data 7)

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Consequently, we then take *OOH as a pivotal and representative model to thoroughly explore the fundamental connection between hydroxyls-synergistic Ru centers and biocatalytic characteristics