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7.6 Anthraquinones: dual modulators of lipogenesis and antioxidant defense Anthraquinones alleviate ALD by suppressing the AMPK/SREBP-1c axis to inhibit de novo lipogenesis and activating the Nrf2/ARE pathway to upregulate antioxidant enzymes such as GST and GR ( Purpurin, an anthraquinone from the roots of Rubia tinctorum L

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doi:10.1016/j.tiv.2009.10.020 Chandrasekaran K, Swaminathan K, Kumar SM, Chatterjee S, Clemens DL, Dey A (2011) Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymesalcohol dehydrogenase and Cytochrome P450 2E1

Published January 12, 2016

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