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In the pregnant rat (30 rats per group), twice-daily exposure to an aerosol of acetylcysteine and isoproterenol for 30 or 35 minutes from the 15th day of gestation through the 21st day postpartum was without adverse effect on dams or newborns

Thus, the most affected tissues are those with the highest proliferative rate: skin, mucous membranes, and bone marrow

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doi: 10.3390/ijms242015068 111 WarnatschATsourouktsoglouTDBranzkNWangQReinckeSHerbstSet al

Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review and meta-analysis