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however, the clinical significance and durability of these effects remain under investigation

10.3109/10715762.2013.789136 33 JaganjacM.MilkovicL.GegotekA.CindricM.ZarkovicK.SkrzydlewskaE.et al (2020)

The reduction in negativity observed in B-NLPs can be attributed to the negative charge of phosphate groups in the DNAzyme backbone at physiological pH 53