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doi: 10.1007/s10350-008-9364-7

Nature Reviews Disease Primers, 10, 28

The study found that solubility and hardness are inversely related, with a softer polymorph being more soluble [38]

S-adenosylmethionine (SAMe), an amino acid derivative important in liver metabolism, and extracts from milk thistle ( Silybum marianum ), have been investigated (alone and in combination) in dogs for their liver-protecting properties and are currently used as part of treatment for a variety of liver diseases in dogs