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10.1111/ijcp.14724 327 MirzaeiR.BouzariB.Hosseini-FardS

ShenYKapfhamerDMinnellaAMKimJEWonSJChenYet al

Stressed and damaged cells, as a result of altered metabolic and physiological states, can produce ROS as a byproduct

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Tracking genetic variants in the biomedical literature using LitVar 2.0

Therefore, various explorations for indirectly targeting KRAS have been performed over the past 40 years, of which most strategies are nonspecific and inefficient, including reducing the expression of KRAS, interrupting the membrane location of KRAS, interfering with the interaction between the KRAS and its effectors, inhibiting upstream and downstream signalling, and synthetic lethality approaches such as cyclin-dependent kinase inhibitors